Abstract:

The X-ray phase problem is the problem of extracting structural information of macromolecules such as proteins directly from the diffraction intensity data of the macromolecular crystals. We have developed a simple mathematical algorithm to solve this problem at medium resolution (around 5 to 8 Angstroms). Structural details of proteins such as the envelope, alpha helices and beta sheets can be determined from the intensity data.
 
 
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